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A Phase III, Randomized, Multicenter, Double-Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime-Avibactam (CAZ-AVI) Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-Abdominal Infections (cIAIs) in Hospitalized Adults

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Trial Profile

A Phase III, Randomized, Multicenter, Double-Blind, Double-Dummy, Parallel-Group, Comparative Study to Determine the Efficacy, Safety, and Tolerability of Ceftazidime-Avibactam (CAZ-AVI) Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-Abdominal Infections (cIAIs) in Hospitalized Adults

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 07 Apr 2022

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At a glance

  • Drugs Avibactam/ceftazidime (Primary) ; Meropenem; Metronidazole
  • Indications Intra-abdominal infections
  • Focus Registrational; Therapeutic Use
  • Acronyms RECLAIM-1
  • Sponsors AstraZeneca

    • Most Recent Events

    • 25 Oct 2020 Results assessing anti-microbial activity ceftazidime-avibactam and comparator agents against enterobacterales and pseudomonas aeruginosa with overexpression of AmpC beta-lactamase from phase 3 studies (RECLAIM , REPRISE, RECAPTURE & REPROVE), presented at the IDWeek 2020.
    • 29 Jun 2020 Results evaluating the safety of ceftazidime-avibactam in adults published in the Drug Safety
    • 21 Apr 2020 Results of an exploratory analysis assessing efficacy and safety of ceftazidime-avibactam in adults with Gram-negative bacteraemia from five phase III randomised clinical trials presented at the 30th European Congress of Clinical Microbiology and Infectious Diseases
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