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A Phase II Randomized, Double-Blind, Study of the Safety and Tolerability of Maraviroc (MVC), Maraviroc + Emtricitabine (MVC+FTC), Maraviroc + Tenofovir Disoproxil Fumarate (MVC+TDF), or Tenofovir Disoproxil Fumarate + Emtricitabine (TDF+FTC) For Pre-Exposure Prophylaxis (PrEP) To Prevent HIV Transmission in At-Risk Men Who Have Sex With Men and in At-Risk Women.

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Trial Profile

A Phase II Randomized, Double-Blind, Study of the Safety and Tolerability of Maraviroc (MVC), Maraviroc + Emtricitabine (MVC+FTC), Maraviroc + Tenofovir Disoproxil Fumarate (MVC+TDF), or Tenofovir Disoproxil Fumarate + Emtricitabine (TDF+FTC) For Pre-Exposure Prophylaxis (PrEP) To Prevent HIV Transmission in At-Risk Men Who Have Sex With Men and in At-Risk Women.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 08 May 2024

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At a glance

  • Drugs Maraviroc (Primary) ; Emtricitabine; Tenofovir disoproxil fumarate
  • Indications HIV infections
  • Focus Adverse reactions
  • Acronyms NEXT-PrEP
  • Most Recent Events

    • 16 Feb 2022 Results presented at the 29th Conference on Retroviruses and Opportunistic Infections
    • 13 Nov 2021 Results of BMD sub study (n=397) published in the Journal of Antimicrobial Chemotherapy.
    • 06 Apr 2021 Results for substudy of HPTN 069/ACTG A5305, assessing differences in colorectal tissue susceptibility to HIV infection between MSM and CGW both before and during antiretroviral dosing, published in the AIDS
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