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A Randomized, Double-Blind, Study Comparing The Pharmacokinetics And Pharmacodynamics, And Assessing The Safety Of PF-05280586 And Rituximab In Subjects With Active Rheumatoid Arthritis On A Background Of Methotrexate Who Have Had An Inadequate Response To One Or More TNF Antagonist Therapies

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A Randomized, Double-Blind, Study Comparing The Pharmacokinetics And Pharmacodynamics, And Assessing The Safety Of PF-05280586 And Rituximab In Subjects With Active Rheumatoid Arthritis On A Background Of Methotrexate Who Have Had An Inadequate Response To One Or More TNF Antagonist Therapies

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 25 Jul 2022

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At a glance

  • Drugs Rituximab (Primary)
  • Indications Rheumatoid arthritis
  • Focus Pharmacokinetics
  • Acronyms REFLECTIONS; REFLECTIONS B328-01
  • Sponsors Pfizer

    • Most Recent Events

    • 25 Jan 2019 The study has been completed in the UK according to European Clinical Trials Database
    • 11 Oct 2016 Results (n=220) assessing similarity of PF-05280586 to rituximab- EU or rituximab-US presented at the 41st European Society for Medical Oncology Congress
    • 16 Aug 2016 Results (n=214) assessing clinical differences in DAS28 or ACR response between PF-05280586 and rituximab- EU or rituximab-US published in the British Journal of Clinical Pharmacology (2016).

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