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A Randomized, Multicenter, Controlled Phase III Study to Compare Perioperative Chemotherapy of Oxaliplatin Combined With S-1(SOX) Versus SOX or Oxaliplatin With Capecitabine (XELOX) as Post-operative Chemotherapy in Locally Advanced Gastric Adenocarcinoma With D2 Dissection

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A Randomized, Multicenter, Controlled Phase III Study to Compare Perioperative Chemotherapy of Oxaliplatin Combined With S-1(SOX) Versus SOX or Oxaliplatin With Capecitabine (XELOX) as Post-operative Chemotherapy in Locally Advanced Gastric Adenocarcinoma With D2 Dissection

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 06 Dec 2023

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At a glance

  • Drugs Gimeracil/oteracil/tegafur (Primary) ; Capecitabine; Capecitabine; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use
  • Acronyms RESOLVE

    • Most Recent Events

    • 24 Oct 2023 Updated Results (n=1022) assessing Overall survival of perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy at 5 years presented at the 48th European Society for Medical Oncology Congress
    • 09 Jul 2021 Primary endpoint has been met. (3 year Disease Free Survival (the non-inferiority of adjuvant-SOX compared with adjuvant-CapOx),as per Results published in the Lancet Oncology
    • 09 Jul 2021 Results published in the Lancet Oncology

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