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A Phase 1/2 Study of ISIS 481464, an Antisense Oligonucleotide Inhibitor of STAT3, Administered to Patients With Advanced Cancers

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Trial Profile

A Phase 1/2 Study of ISIS 481464, an Antisense Oligonucleotide Inhibitor of STAT3, Administered to Patients With Advanced Cancers

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Danvatirsen (Primary)
  • Indications Diffuse large B cell lymphoma; Hodgkin's disease; Non-Hodgkin's lymphoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Ionis Pharmaceuticals

    • Most Recent Events

    • 17 Sep 2020 Results of patient samples (Paired biopsies and blood sample) taken from this study to assess its immunomodulatory mechanism of action published in the Clinical Cancer Research
    • 07 May 2018 Status changed from active, no longer recruiting to completed.
    • 04 Jan 2016 Planned End Date changed from 1 Mar 2015 to 1 Jul 2016 as reported by ClinicalTrials.gov.

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