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TBTC Study 33. An Evaluation of Adherence to Latent Tuberculosis Infection (LTBI) Treatment With 12 Doses of Once Weekly Rifapentine (RPT) and Isoniazid (INH) Given as Self-administered (SAT) Versus Directly-observed Therapy (DOT): iAdhere.

Trial Profile

TBTC Study 33. An Evaluation of Adherence to Latent Tuberculosis Infection (LTBI) Treatment With 12 Doses of Once Weekly Rifapentine (RPT) and Isoniazid (INH) Given as Self-administered (SAT) Versus Directly-observed Therapy (DOT): iAdhere.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Mar 2025

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At a glance

  • Drugs Isoniazid (Primary) ; Rifapentine (Primary)
  • Indications Tuberculosis
  • Focus Therapeutic Use
  • Acronyms iAdhere

Most Recent Events

  • 23 Feb 2023 Results assessing the patterns of symptom development and identify SDR and associated factors in patients on 3 months of weekly rifapentine plus isoniazid, published in the Clinical Infectious Diseases.
  • 18 May 2016 Results of post-hoc analysis of two phase III studies (PREVENT TB and iAdhere) presented at the 112th International Conference of the American Thoracic Society
  • 01 Dec 2012 Additional lead trial centre added as reported by European Clinical Trials Database record.

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