Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Alone

Trial Profile

Randomized, Double-blind, Placebo-controlled, Multicenter, Phase IIb Dose Finding Study of GLPG0634 Administered for 24 Weeks in Combination With Methotrexate to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Alone

Completed
Phase of Trial: Phase II

Latest Information Update: 16 Jun 2018

At a glance

  • Drugs Filgotinib (Primary) ; Methotrexate
  • Indications Rheumatoid arthritis
  • Focus Therapeutic Use
  • Acronyms DARWIN-1
  • Sponsors Galapagos NV
  • Most Recent Events

    • 16 Jun 2018 Results of RNA sequencing gene profiling in blood samples from two studies (DARWIN-1 and DARWIN-2) presented at the 19th Annual Congress of the European League Against Rheumatism.
    • 08 Nov 2017 Safety results summarized from DARWIN-1, DARWIN-2 and DARWIN-3 trials and efficacy results from DARWIN-3 trial presented at the 81st American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting
    • 08 Nov 2017 Results of a post-hoc analysis two phase IIb studies (DARWIN-1 and DARWIN-2) assessing utility of a Multi Biomarker Disease Activity (MBDA) score in relation to clinical disease activity assessments in patients treated with filgotinib, were presented at the 81st American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting.
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