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A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Subjects With Active Rheumatoid Arthritis Despite DMARD Therapy

Trial Profile

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study of CNTO 136 (Sirukumab), a Human Anti-IL-6 Monoclonal Antibody, Administered Subcutaneously, in Subjects With Active Rheumatoid Arthritis Despite DMARD Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 23 Feb 2024

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At a glance

  • Drugs Sirukumab (Primary)
  • Indications Rheumatoid arthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms SIRROUND-D
  • Sponsors Janssen Research & Development

Most Recent Events

  • 23 Sep 2020 Results of retrospective analysis by using data from four phase III studies (SIRROUND- D, SIRROUND-T, GO-BEFORE and GO-FORWARD) presented at the 2020 American College of Clinical Pharmacology Annual Meeting.
  • 24 Oct 2018 Results presented at the 82nd American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting
  • 14 Jun 2018 Results of an exposure-response modelling analysis from SIRROUND-D and SIRROUND-T studies, published in the Journal of Clinical Pharmacology.

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