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Randomized, Double-blind, Phase 3 Study of TAS-102 Plus Best Supportive Care Versus Placebo Plus BSC in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies

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Trial Profile

Randomized, Double-blind, Phase 3 Study of TAS-102 Plus Best Supportive Care Versus Placebo Plus BSC in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 25 Sep 2024

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At a glance

  • Drugs Tipiracil/trifluridine (Primary)
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms RECOURSE
  • Sponsors Taiho Oncology

    • Most Recent Events

    • 06 Jun 2023 Results of Matching-adjusted indirect treatment comparison assessing the efficacy and safety of sotorasib with standard of care trifluridine/tipiracil and regorafenib as monotherapy treatments using data from NCT01607957, NCT01103323 and NCT03600883 trials, presented at the 59th Annual Meeting of the American Society of Clinical Oncology.
    • 07 Jun 2022 Results (n=37) of an analysis assessing overall survival benefit of trifluridine-tipiracil in patients with metastatic colorectal cancer from discovery cohort presented at the 58th Annual Meeting of the American Society of Clinical Oncology
    • 22 Jan 2022 Results of a pooled analysis (NCT02122913, NCT02637687, NCT02576431, NCT01607957 and NCT01103323 )comparing the expected life-years and quality-adjusted life-years for metastatic CRC patients eligible to receive larotrectinib, regorafenib or trifluridine/tipiracil.presented at the 2022 Gastrointestinal Cancers Symposium

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