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A Phase I Study of the Safety, Pharmacokinetics and Pharmacodynamics of Escalating Doses of the Selective Inhibitor of Nuclear Export (SINE) KPT- 330 in Patients With Advanced or Metastatic Solid Tumor Malignancies

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Trial Profile

A Phase I Study of the Safety, Pharmacokinetics and Pharmacodynamics of Escalating Doses of the Selective Inhibitor of Nuclear Export (SINE) KPT- 330 in Patients With Advanced or Metastatic Solid Tumor Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 30 Jan 2023

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At a glance

  • Drugs Paracetamol (Primary) ; Selinexor (Primary)
  • Indications Adenocarcinoma; Anaplastic astrocytoma; Carcinoma; Cervical cancer; Colorectal cancer; Fallopian tube cancer; Glioblastoma; Gynaecological cancer; Head and neck cancer; Liver metastases; Malignant melanoma; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man
  • Sponsors Karyopharm Therapeutics; NPM Pharma

    • Most Recent Events

    • 06 Apr 2021 Study design changed from single group assignment to parallel assignment
    • 21 Mar 2020 Results presented at the 121st Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
    • 31 Mar 2017 Status changed from active, no longer recruiting to completed.

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