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A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease

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Trial Profile

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 24 Jun 2025

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At a glance

  • Drugs Evolocumab (Primary) ; HMG-CoA reductase inhibitors
  • Indications Atherosclerosis; Cardiovascular disorders; Hyperlipidaemia; Myocardial infarction; Stroke
  • Focus Registrational; Therapeutic Use
  • Acronyms FOURIER; PROFICIO
  • Sponsors Amgen

Most Recent Events

  • 18 Jun 2025 According to an Amgen media release, data from this study will be presented at the 85th American Diabetes Association (ADA) Scientific Sessions taking place from June 20-23, 2025, in Chicago.
  • 18 Nov 2024 Results discussing Association Between Lipoprotein(a) Levels and Incident Complex Coronary Revascularization Procedures , presented at the American Heart Association Scientific Sessions 2024
  • 18 Nov 2024 Results studying Changes in high-sensitivity cardiac troponin I and associated cardiovascular risk, presented at the American Heart Association Scientific Sessions 2024

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