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A Randomized, Open-Label, Phase 3 Study of Nivolumab (BMS-936558) vs. Everolimus in Subjects with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma Who Have Received Prior Anti-Angiogenic Therapy

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Trial Profile

A Randomized, Open-Label, Phase 3 Study of Nivolumab (BMS-936558) vs. Everolimus in Subjects with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma Who Have Received Prior Anti-Angiogenic Therapy

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 08 Jul 2024

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At a glance

  • Drugs Nivolumab (Primary) ; Everolimus
  • Indications Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms CheckMate-025
  • Sponsors Bristol-Myers Squibb

    • Most Recent Events

    • 04 Jun 2024 Results analyzing the association between a germline IL7 SNP (rs16906115) and AEs in patients with mRCC treated with nivolumab (NIVO) or everolimus , presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 07 Dec 2023 Results assessing whether PD-1 expression on intratumoral regulatory T cells is associated with lack of benefit from Anti-PD-1 therapy in metastatic clear cell renal cell carcinoma patients using multiparametric immunofluorescence in ccRCC tissues obtained from this study published in the Clinical Cancer Research
    • 01 Dec 2023 This trial has been completed in Spain (Date of the global end of the trial: 19-Jul-2021), according to the European Clinical Trials Database record.

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