Neo-/Adjuvant Phase III Trial to Compare Intense Dose-dense Chemotherapy to Tailored Dose-dense Chemotherapy in Patients With High-risk Early Breast Cancer (GAIN-2)

Trial Profile

Neo-/Adjuvant Phase III Trial to Compare Intense Dose-dense Chemotherapy to Tailored Dose-dense Chemotherapy in Patients With High-risk Early Breast Cancer (GAIN-2)

Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 05 Jun 2018

At a glance

  • Drugs Cyclophosphamide (Primary) ; Epirubicin (Primary) ; Paclitaxel (Primary) ; Docetaxel; Trastuzumab
  • Indications Early breast cancer
  • Focus Biomarker; Pharmacogenomic; Therapeutic Use
  • Acronyms GAIN-2
  • Most Recent Events

    • 05 Jun 2018 Results (n=598) assessing pathological complete response, presented at the 54th Annual Meeting of the American Society of Clinical Oncology.
    • 09 Dec 2017 Pharmacokinetic results (n=30) of a subcutaneous injection of trastuzumab into the thigh versus into the abdominal wall in patients treated in the GAIN-2 study, presented at the 40th Annual San Antonio Breast Cancer Symposium
    • 10 Jul 2017 Status changed from recruiting to active, no longer recruiting.
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