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Randomized comparison of two different treatment concepts in newly diagnosed acute promyelocytic leukemia (APL). A randomized study for comparison of the effects of ATRA and intensified double induction therapy incorporating high dose ara-C followed by TAD consolidation and cyclic maintenance therapy (AMLCG concept) and induction therapy with ATRA and idarubicin (AIDA) followed by three anthracyclin/ATRA- based consloidation courses and maintenance therapy (PETHEMA conzept).

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Randomized comparison of two different treatment concepts in newly diagnosed acute promyelocytic leukemia (APL). A randomized study for comparison of the effects of ATRA and intensified double induction therapy incorporating high dose ara-C followed by TAD consolidation and cyclic maintenance therapy (AMLCG concept) and induction therapy with ATRA and idarubicin (AIDA) followed by three anthracyclin/ATRA- based consloidation courses and maintenance therapy (PETHEMA conzept).

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 28 May 2019

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At a glance

  • Drugs Tretinoin (Primary) ; Cyclophosphamide; Cytarabine; Cytarabine; Daunorubicin; Idarubicin; Mercaptopurine; Methotrexate; Mitoxantrone; Tioguanine
  • Indications Acute promyelocytic leukaemia
  • Focus Therapeutic Use

    • Most Recent Events

    • 04 Sep 2012 New trial record

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