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A Phase I, Randomised, Double-blind, 3-Part Study in Healthy Young and Elderly Subjects to Assess the Safety and Tolerability, and Investigate the Pharmacokinetics of Aztreonam and Avibactam Given Alone and in Combination (ATM-AVI)

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Trial Profile

A Phase I, Randomised, Double-blind, 3-Part Study in Healthy Young and Elderly Subjects to Assess the Safety and Tolerability, and Investigate the Pharmacokinetics of Aztreonam and Avibactam Given Alone and in Combination (ATM-AVI)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 30 May 2019

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At a glance

  • Drugs Avibactam (Primary) ; Avibactam/aztreonam (Primary) ; Aztreonam (Primary)
  • Indications Gram-negative infections; Intra-abdominal infections
  • Focus Adverse reactions
  • Sponsors AstraZeneca

    • Most Recent Events

    • 16 Apr 2019 Results assessing pharmacokinetic-pharmacodynamic modelling from this study, presented at the 29th European Congress of Clinical Microbiology and Infectious Diseases.
    • 27 Jan 2015 Status changed from recruiting to completed as reported by ClinicalTrials.gov record.
    • 16 Sep 2014 Planned end date changed from 1 Jun 2015 to 1 Feb 2015 as reported by ClinicalTrials.gov.

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