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A Pharmacodynamically-guided, Dose-escalation, Phase I Study to Assess the Safety of AFM11 (Recombinant Antibody Construct Against Human CD19 and CD3) in Patients With Relapsed and/or Refractory CD19 Positive B-cell NHL

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Trial Profile

A Pharmacodynamically-guided, Dose-escalation, Phase I Study to Assess the Safety of AFM11 (Recombinant Antibody Construct Against Human CD19 and CD3) in Patients With Relapsed and/or Refractory CD19 Positive B-cell NHL

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 16 Jan 2023

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At a glance

  • Drugs AFM 11 (Primary)
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions
  • Sponsors Affimed Therapeutics

    • Most Recent Events

    • 03 Jan 2023 Results (n=16; AFM11-101 and n=17; AFM11-102) assessing the safety of AFM11 in the treatment of patients with B-cell malignancies from NCT02106091 and NCT02848911 studies, published in the Trials.
    • 15 May 2019 Status changed from suspended to discontinued.
    • 15 Oct 2018 Planned End Date changed from 1 Sep 2018 to 1 Jul 2019.
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