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A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors

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Trial Profile

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 Dec 2022

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At a glance

  • Drugs Baricitinib (Primary)
  • Indications Rheumatoid arthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms RA-BEACON
  • Sponsors Eli Lilly and Company; Lilly Korea

    • Most Recent Events

    • 07 Dec 2022 Results from NCT01710358 and NCT01721044 assessing the relative impact of pain and disease activity on improvements in fatigue, published in the JCR: Journal of Clinical Rheumatology
    • 09 Nov 2021 Results assessing effects of Baricitinib on fatigue that are influenced by disease activity and those that are independent of disease activity in patients from the RA-BEAM and RA-BEACON trials, presented at the ACR Convergence 2021
    • 09 Nov 2021 Results of post-hoc analysis of 3 studies (RA-BEGIN (NCT01711359); RA-BEAM (NCT01710358) & RA-BEACON (NCT01721044)) assessing the relative importance of PROs on the Patient Global Assessment of Disease Activity (PtGA) and health-related quality of life (HRQoL) and whether these differ in patients with good disease control compared with those not in low disease activity (LDA) or remission in different patient populations, presented at the ACR Convergence 2021.
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