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A Phase 1 First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 232 in Adult Subjects With Advanced Solid Tumors or Multiple Myeloma

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Trial Profile

A Phase 1 First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 232 in Adult Subjects With Advanced Solid Tumors or Multiple Myeloma

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Navtemadlin (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Bone cancer; Carcinoid tumour; Cholangiocarcinoma; Colon cancer; Endometrial cancer; Glioblastoma; Head and neck cancer; Liposarcoma; Malignant melanoma; Mesothelioma; Multiple myeloma; Neuroendocrine carcinoma; Non-small cell lung cancer; Oesophageal cancer; Pancreatic cancer; Prostate cancer; Rectal cancer; Renal cell carcinoma; Salivary gland cancer; Soft tissue sarcoma; Solid tumours; Thyroid cancer
  • Focus Adverse reactions; First in man
  • Sponsors Kartos Therapeutics

    • Most Recent Events

    • 21 Jun 2020 Results assessing the effect of KRT-232 exposure on MIC-1 fold change from baseline and evaluate baseline serum MIC-1 level as a covariate in a PD exposure-response (E-R) model using data from two trials (NCT02016729 and NCT01723020), were presented at the 25th Congress of the European Haematology Association.
    • 29 Jul 2019 Results published in the Investigational New Drugs
    • 04 Oct 2017 Status changed from active, no longer recruiting to completed.

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