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Phase III Study Evaluating Palbociclib (PD-0332991), a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor in Patients With Hormone-receptor-positive, HER2-normal Primary Breast Cancer With High Relapse Risk After Neoadjuvant Chemotherapy "PENELOPEB"

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Phase III Study Evaluating Palbociclib (PD-0332991), a Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor in Patients With Hormone-receptor-positive, HER2-normal Primary Breast Cancer With High Relapse Risk After Neoadjuvant Chemotherapy "PENELOPEB"

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 02 Jul 2024

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At a glance

  • Drugs Palbociclib (Primary) ; Gonadotropin releasing hormone stimulants; Tamoxifen
  • Indications Carcinoma; Early breast cancer; HER2 negative breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PENELOPE-B

    • Most Recent Events

    • 04 Jun 2024 Results assessing Relationship of adaptive subtyping and tumour heterogeneity of treatment response to neoadjuvant therapy in hormone receptor positive HER2-negative early breast cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 05 Nov 2023 Results of Patient-reported outcomes in high-risk HR+ /HER2- early breast cancer patients treated with endocrine therapy with or without palbociclib within this study, published in the European Journal of Cancer
    • 06 Jun 2023 Results assessing the potential of ctDNA analysis to predict future clinical relapse for patients enrolled in the PENELOPE-B trial, presented at the 59th Annual Meeting of the American Society of Clinical Oncology.

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