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A 52-Week, Phase 3, Randomized, Active Comparator and Placebo-Controlled, Parallel Design Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous Tildrakizumab (SCH 900222/MK-3222), Followed by an Optional Long-Term Safety Extension Study, in Subjects With Moderate-to-Severe Chronic Plaque Psoriasis (Protocol No. MK-3222-011)

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A 52-Week, Phase 3, Randomized, Active Comparator and Placebo-Controlled, Parallel Design Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous Tildrakizumab (SCH 900222/MK-3222), Followed by an Optional Long-Term Safety Extension Study, in Subjects With Moderate-to-Severe Chronic Plaque Psoriasis (Protocol No. MK-3222-011)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 06 Jul 2023

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At a glance

  • Drugs Tildrakizumab (Primary) ; Etanercept
  • Indications Plaque psoriasis
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms reSURFACE 2
  • Sponsors Merck Sharp & Dohme Corp.; Sun Pharma Global FZE

    • Most Recent Events

    • 06 Jul 2023 Results published in Results of Pooled analysis of 5-year safety data from reSURFACE 1 and reSURFACE 2; published in the Journal of Dermatological TreatmentJournal of Dermatological Treatment
    • 21 Mar 2023 Results of Pooled analyses from reSURFACE 1 and reSURFACE 2; analyzing efficacy and safety of tildrakizumab in patients with moderate-to-severe plaque psoriasis across age quartiles, presented at the American Academy of Dermatology annual Meeting 2023
    • 26 Sep 2022 Results of post-hoc analysis of two studies (reSURFACE 1 (NCT01722331) and reSURFACE 2 (NCT01729754) ) assessing tildrakizumab efficacy and safety for up to 5 years in patients with and without metabolic syndrome, published in the Journal of the European Academy of Dermatology and Venereology.

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