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A Pilot Study to Determine the Effects of the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 on Leukemia Cell Kinetics and Trafficking, Using Heavy Water Labeling in Subjects With Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

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Trial Profile

A Pilot Study to Determine the Effects of the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 on Leukemia Cell Kinetics and Trafficking, Using Heavy Water Labeling in Subjects With Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 19 Jan 2023

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At a glance

  • Drugs Ibrutinib (Primary)
  • Indications Chronic lymphocytic leukaemia
  • Focus Biomarker; Therapeutic Use

    • Most Recent Events

    • 13 Dec 2022 Results assessing long-term outcomes and correlated chronic lymphocytic leukemia cell birth and death rates with depth of response over time, presented at the 64th American Society of Hematology Annual Meeting and Exposition.
    • 15 Aug 2018 Status changed from active, no longer recruiting to completed.
    • 05 Mar 2018 Planned End Date changed from 1 Dec 2018 to 1 Dec 2020.

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