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An Open-label, Single Arm, Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma With 17p Deletion (RESONATE-17)

Trial Profile

An Open-label, Single Arm, Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma With 17p Deletion (RESONATE-17)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 19 Jun 2023

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At a glance

  • Drugs Ibrutinib (Primary)
  • Indications Chronic lymphocytic leukaemia
  • Focus Therapeutic Use
  • Acronyms RESONATE-17; RESONATE-17p
  • Sponsors Pharmacyclics

Most Recent Events

  • 14 Jun 2023 Results assessing frequency and time to detection of BTK and PLCG2 mutations in peripheral blood samples across 5 clinical trials (NCT01500733, NCT01578707, NCT01722487, NCT01744691 and NCT02264574) published in the Clinical Cancer Research
  • 07 Oct 2020 Development and validation of a four-factor prognostic model in Patients With Chronic Lymphocytic Leukemia treated with Ibrutinib; results published in the Journal of Clinical Oncology
  • 04 Dec 2018 Results of validation of prognostic model using pooled data of pooled analysis of four phase II and III studies (NCT01105247; NCT01578707; NCT01722487; NCT01744691), presented at the 60th Annual Meeting and Exposition of the American Society of Hematology.

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