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A Phase I Study in Patients Treated With MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment

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A Phase I Study in Patients Treated With MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Ferumoxytol (Primary) ; Irinotecan (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Brain metastases; Colorectal cancer; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Triple negative breast cancer
  • Focus Diagnostic use; Pharmacokinetics
  • Sponsors Ipsen; Merrimack Pharmaceuticals

    • Most Recent Events

    • 31 May 2019 Results assessing the pharmacokinetic profile of nal-IRI in patients with metastatic breast cancer published in conjunction with 55th Annual Meeting of the American Society of Clinical Oncology (2019)
    • 03 Apr 2019 Results presented at the 110th Annual Meeting of the American Association for Cancer Research
    • 31 Oct 2018 Status changed from active, no longer recruiting to completed.

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