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A Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Overweight Social Drinkers.

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A Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Overweight Social Drinkers.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Sep 2023

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At a glance

  • Drugs GSK 1521498 (Primary) ; Naltrexone
  • Indications Alcoholism; Obesity
  • Focus Adverse reactions; Pharmacodynamics; Pharmacogenomic
  • Sponsors GlaxoSmithKline; GSK

    • Most Recent Events

    • 13 Jun 2014 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov record.
    • 09 May 2014 Status changed from recruiting to active, no longer recruiting as reported by ClinicalTrials.gov record.
    • 01 Nov 2013 Planned end date changed from 1 Sep 2013 to 1 Jun 2014 as reported by ClinicalTrials.gov.

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