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A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Trastuzumab Emtansine (T-DM1) With or Without Standard Endocrine Therapy vs. Trastuzumab With Standard Endocrine Therapy Given for Twelve Weeks in Patients With Operable HER2+/HR+ Breast Cancer Within the ADAPT Protocol. [SUBSTUDY OF 700216591]

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A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Trastuzumab Emtansine (T-DM1) With or Without Standard Endocrine Therapy vs. Trastuzumab With Standard Endocrine Therapy Given for Twelve Weeks in Patients With Operable HER2+/HR+ Breast Cancer Within the ADAPT Protocol. [SUBSTUDY OF 700216591]

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 27 Mar 2023

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At a glance

  • Drugs Trastuzumab emtansine (Primary) ; Tamoxifen; Trastuzumab
  • Indications Advanced breast cancer; Carcinoma; Early breast cancer
  • Focus Therapeutic Use
  • Acronyms ADAPT-HER2+HR+; ADAPT-TP; WSG-ADAPT-TP

    • Most Recent Events

    • 23 Mar 2023 Planned End Date changed from 1 Oct 2020 to 1 Oct 2024.
    • 12 Feb 2023 Results reporting secondary survival end points and biomarker analysis published in the Journal of Clinical Oncology
    • 14 Dec 2019 Results of impact of immune merkers on response by using data from this study presented at the 42nd Annual San Antonio Breast Cancer Symposium.

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