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A Randomized Controlled Phase 3 Study of Oral Pacritinib Versus Best Available Therapy in Patients With Thrombocytopenia and Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

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Trial Profile

A Randomized Controlled Phase 3 Study of Oral Pacritinib Versus Best Available Therapy in Patients With Thrombocytopenia and Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 08 Jul 2024

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At a glance

  • Drugs Pacritinib (Primary) ; Ruxolitinib
  • Indications Myelofibrosis
  • Focus Registrational; Therapeutic Use
  • Acronyms PERSIST-2
  • Sponsors Cell Therapeutics; CTI BioPharma
  • Most Recent Events

    • 04 Jun 2024 Results representing data on spleen and symptom benefit in PAC-treated pts with moderate or severe bicytopenia. presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 04 Jun 2024 Results evaluating the impact of PAC versus best available therapy (BAT), including ruxolitinib (RUX), on symptom burden in patients with baseline RBC transfusions presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 12 Dec 2023 Results (n=41) evaluating relationship between transfusion independence and reduction in BMF in MF patients treated with pacritinib, presented at the 65th American Society of Hematology Annual Meeting and Exposition

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