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Preoperative radiochemotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: a multicentre randomized phase III clinical trial (PREOPANC )

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Trial Profile

Preoperative radiochemotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: a multicentre randomized phase III clinical trial (PREOPANC )

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Sep 2023

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At a glance

  • Drugs Gemcitabine (Primary)
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus Therapeutic Use
  • Acronyms PREOPANC

    • Most Recent Events

    • 14 Sep 2023 Results investigating sex disparities in clinical outcomes and tumour immune profiles in patients with pancreatic ductal adenocarcinoma (PDAC) who underwent upfront resection or resection preceded by gemcitabine-based neoadjuvant chemoradiotherapy, published in the Gut
    • 01 May 2022 Results investigating the accrual proportion and patients reasons for not participating in the PREOPANC trial on neoadjuvant chemoradiotherapy versus immediate surgery in resectable and borderline resectable pancreatic cancer, and comparing these patients outcomes with those of patients who had been randomized in the trial, published in the Annals of Surgery
    • 27 Feb 2020 Primary endpoint (Overall survival) has not been met, as per results published in the Journal of Clinical Oncology.

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