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A Randomized Placebo-controlled Phase II Trial of Irradiated, Adenovirus Vector Transferred GM-CSF Secreting Autologous Leukemia Cell Vaccination (GVAX) Versus Placebo Vaccination in Patients With Advanced MDS/AML After Allogeneic Hematopoietic Stem Cell Transplantation

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A Randomized Placebo-controlled Phase II Trial of Irradiated, Adenovirus Vector Transferred GM-CSF Secreting Autologous Leukemia Cell Vaccination (GVAX) Versus Placebo Vaccination in Patients With Advanced MDS/AML After Allogeneic Hematopoietic Stem Cell Transplantation

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 19 Jul 2022

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At a glance

  • Drugs Tumour cell vaccine-GVAX (Primary) ; Busulfan; Fludarabine; Methotrexate; Tacrolimus
  • Indications Acute myeloid leukaemia; Graft-versus-host disease; Myelodysplastic syndromes
  • Focus Therapeutic Use

    • Most Recent Events

    • 30 Jun 2022 Status changed from active, no longer recruiting to discontinued.
    • 02 Jun 2020 Planned End Date changed from 1 Jan 2033 to 1 Jan 2035.
    • 02 Jun 2020 Status changed from recruiting to active, no longer recruiting.

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