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A Phase II Trial of Neoadjuvant MK-2206 in Combination With Either Anastrozole if Postmenopausal or Anastrozole and Goserelin if Premenopausal in Women With Clinical Stage 2 or 3 PIK3CA Mutant Estrogen Receptor Positive and HER2 Negative Invasive Breast Cancer

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A Phase II Trial of Neoadjuvant MK-2206 in Combination With Either Anastrozole if Postmenopausal or Anastrozole and Goserelin if Premenopausal in Women With Clinical Stage 2 or 3 PIK3CA Mutant Estrogen Receptor Positive and HER2 Negative Invasive Breast Cancer

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs MK 2206 (Primary) ; Anastrozole; Goserelin
  • Indications Advanced breast cancer; Early breast cancer; HER2 negative breast cancer
  • Focus Proof of concept; Therapeutic Use

    • Most Recent Events

    • 06 Apr 2018 Status changed from active, no longer recruiting to discontinued as the study did not pass stage 1 interim analysis
    • 05 Sep 2017 Primary endpoint (Pathological complete response based on tumor Ki-67 value [ Time Frame: Up to day 17 of course 1 ]) has not been met as per the results published in the Clinical cancer research: an official journal of the American Association for Cancer Research
    • 05 Sep 2017 Results published in the Clinical cancer research: an official journal of the American Association for Cancer Research

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