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Phase II, Open Label, Single Arm Study of the Efficacy and Safety of Crizotinib in East Asian Patients With Advanced ALK-Negative NSCLC Harboring a Translocation or Inversion Involving the c-ROS Oncogene (ROS1) Locus

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Trial Profile

Phase II, Open Label, Single Arm Study of the Efficacy and Safety of Crizotinib in East Asian Patients With Advanced ALK-Negative NSCLC Harboring a Translocation or Inversion Involving the c-ROS Oncogene (ROS1) Locus

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 25 Oct 2023

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At a glance

  • Drugs Crizotinib (Primary)
  • Indications Adenocarcinoma; Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms The OxOnc Study
  • Sponsors OxOnc Development; Pfizer

    • Most Recent Events

    • 12 Sep 2023 Results assessing Individual patient data (IPD) from entrectinib trials (ALKA-372-001/EudraCT 2012-000148-88, STARTRK-1/NCT02097810 and STARTRK-2/NCT02568267) and aggregate data from a crizotinib trial (OxOnc/NCT01945021) using unanchored matching adjusted indirect comparison, presented at the 24th World Conference on Lung Cancer.
    • 14 Sep 2021 Results of an analysis assessing the updated OS and safety after an additional 3 years of follow-up presented at the 2021 World Conference on Lung Cancer
    • 24 Apr 2020 Status changed from active, no longer recruiting to completed.

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