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A randomised phase IIb trial of bevacizumab added to temozolomide ± irinotecan for children with refractory/relapsed neuroblastoma – BEACON-Neuroblastoma Trial

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Trial Profile

A randomised phase IIb trial of bevacizumab added to temozolomide ± irinotecan for children with refractory/relapsed neuroblastoma – BEACON-Neuroblastoma Trial

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 28 May 2024

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At a glance

  • Drugs Bevacizumab (Primary) ; Dinutuximab beta (Primary) ; Temozolomide (Primary) ; Cyclophosphamide; Irinotecan; Topotecan
  • Indications Neuroblastoma
  • Focus Registrational; Therapeutic Use
  • Acronyms BEACON; BEACON-Immuno; BEACON-Neuroblastoma Trial; ITCC-SIOPEN BEACON
  • Most Recent Events

    • 22 May 2024 According to an ORPHELIA Pharma, overall, anonymised data from the BEACON trial are being used to support the registration dossier of KIZFIZO, according to a data sharing agreement drawn up by University of Birmingham Enterprise. The data from this trial will support registration of for a new liquid formulation temozolomide.
    • 13 May 2024 Planned End Date changed from 1 Dec 2026 to 1 Feb 2026.
    • 08 Jan 2024 Primary endpoint has not been met. (Best response (Complete Response or Partial Response) while on trial treatment, within 18 or 24 weeks depending on the arm of the trial participant is randomised to), as per Results published in the Journal of Clinical Oncology
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