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A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy

Trial Profile

A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 18 Oct 2019

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At a glance

  • Drugs Cabozantinib (Primary) ; Everolimus
  • Indications Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms METEOR
  • Sponsors Exelixis
  • Most Recent Events

    • 01 Aug 2019 Results assessing correlative biomarker analysis in two independent clinical trials of cabozantinib (METEOR and CABOSUN), by examining associations between clinical outcomes and PD-L1 expression assessed by immunohistochemistry published in the Clinical Cancer Research
    • 31 Jul 2019 This trial has been completed in Ireland, according to European Clinical Trials Database.
    • 25 Apr 2019 According to an Exelixis media release, Takeda (its partner) has applied to the Japanese Ministry of Health, Labor and Welfare (MHLW) for approval to manufacture and sell CABOMETYX (cabozantinib) as a treatment for unresectable and metastatic renal cell carcinoma (RCC) in the country.Takeda's application is based on the results of three clinical trials: METEOR, CABOSUN trials as well Takeda bridging study (Cabozantinib-2001).
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