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A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy

Trial Profile

A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 26 Nov 2020

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At a glance

  • Drugs Cabozantinib (Primary) ; Everolimus
  • Indications Renal cell carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms METEOR
  • Sponsors Exelixis
  • Most Recent Events

    • 21 Sep 2020 Trial design presented at the 45th European Society for Medical Oncology Congress
    • 31 May 2020 Results of post-hoc pooled analysis of patients who had received prior IO therapy from METEOR and C2001 presented at the 56th Annual Meeting of the American Society of Clinical Oncology
    • 25 Mar 2020 According to an Exelixis media release, the company announced that Takeda Pharmaceutical Company Limited (Takeda) has received approval from the Japanese Ministry of Health, Labor and Welfare to manufacture and market CABOMETYX as a treatment for patients with curatively unresectable or metastatic renal cell carcinoma (RCC). The approval is based on the results of three clinical trials: METEOR, CABOSUN and Cabozantinib-2001.
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