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Phase I study of safety and immune effects of an escalating dose of autologous GD2 chimeric antigen receptor-expressing peripheral blood T cells in patients with metastatic melanoma

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Trial Profile

Phase I study of safety and immune effects of an escalating dose of autologous GD2 chimeric antigen receptor-expressing peripheral blood T cells in patients with metastatic melanoma

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 14 Nov 2023

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At a glance

  • Drugs Anti GD2 CAR transduced T cells (Primary) ; Vemurafenib
  • Indications Colorectal cancer; Ewing's sarcoma; Fibrosarcoma; Liposarcoma; Malignant melanoma; Osteosarcoma; Rhabdomyosarcoma; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Synovial sarcoma; Triple negative breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms CARPETS
  • Most Recent Events

    • 23 Sep 2023 Primary endpoint (The feasibility of preparing T cell products for administration to patients receiving vemurafenib will be determined as the frequency of successfully administered products. Acceptable feasibility is defined as the administration to patients of or equal to 75% of prepared T cells products.) has been met according to result presented at the CRI-ENCI-AACR: 7th Annual International Cancer, Immunotherapy Conference.
    • 23 Sep 2023 Status changed from not yet recruiting to active, no longer recruiting according to result presented at the CRI-ENCI-AACR: 7th Annual International Cancer, Immunotherapy Conference.
    • 23 Sep 2023 Results presented at the CRI-ENCI-AACR: 7th Annual International Cancer, Immunotherapy Conference
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