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A Multicenter, Open Label Phase I/II Study to Determine the Safety and Immune Modulating Effects of the Therapeutic Human Papilloma Virus 16 (HPV16) E6/E7 Long Peptides Vaccine (ISA101/ISA101b) Immunotherapy in Combination With Standard of Care Therapy (Carboplatin and Paclitaxel With or Without Bevacizumab) in Women With HPV16 Positive Advanced or Recurrent Cervical Cancer Who Have no Curative Treatment Options

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Trial Profile

A Multicenter, Open Label Phase I/II Study to Determine the Safety and Immune Modulating Effects of the Therapeutic Human Papilloma Virus 16 (HPV16) E6/E7 Long Peptides Vaccine (ISA101/ISA101b) Immunotherapy in Combination With Standard of Care Therapy (Carboplatin and Paclitaxel With or Without Bevacizumab) in Women With HPV16 Positive Advanced or Recurrent Cervical Cancer Who Have no Curative Treatment Options

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 09 Feb 2022

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At a glance

  • Drugs ISA 101 (Primary) ; Bevacizumab; Carboplatin; Paclitaxel; Peginterferon alfa-2b
  • Indications Adenosquamous carcinoma; Cervical cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms CervlSA
  • Sponsors ISA Pharmaceuticals

    • Most Recent Events

    • 19 Mar 2020 According to an ISA Pharmaceuticals Media Release, phase II data was published in in the peer-reviewed journal "Science Translational Medicine".
    • 19 Mar 2020 Results of phase II data published in the ISA Pharmaceuticals Media Release
    • 05 Mar 2019 Status changed from active, no longer recruiting to completed.

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