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An Open-Label, Non-Randomized, Multicenter Phase I/II Trial of RO5424802 Given Orally to Non-Small Cell Lung Cancer Patients Who Have ALK Mutation and Who Have Failed Crizotinib Treatment

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An Open-Label, Non-Randomized, Multicenter Phase I/II Trial of RO5424802 Given Orally to Non-Small Cell Lung Cancer Patients Who Have ALK Mutation and Who Have Failed Crizotinib Treatment

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 07 Apr 2022

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At a glance

  • Drugs Alectinib (Primary) ; Erlotinib
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms Study 2
  • Sponsors Roche

    • Most Recent Events

    • 08 Nov 2019 Results (n=187) of exploratory analysis using pooled data from two clinical studies (NP28673 and NP28761) were published in the Journal of Thoracic Oncology
    • 05 Jun 2018 Results (n=207) of an exposure-response analysis of alectinib in crizotinib-resistant ALK-positive non-small cell lung cancer patients using final pooled phase II OS and safety data (NCT01801111 and NCT01871805), presented at the 54th Annual Meeting of the American Society of Clinical Oncology.
    • 05 Jun 2018 Results of a pooled analysis of NP28673 and NP28761 trials (n=225) assessing the survival and safety, presented at the 54th Annual Meeting of the American Society of Clinical Oncology

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