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A Multicenter, Randomized, Controlled, Three-Arm, Phase III Study to Evaluate the Safety and Efficacy of Two Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Patients With Advanced Melanoma

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Trial Profile

A Multicenter, Randomized, Controlled, Three-Arm, Phase III Study to Evaluate the Safety and Efficacy of Two Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Patients With Advanced Melanoma

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 30 Sep 2024

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At a glance

  • Drugs Pembrolizumab (Primary) ; Ipilimumab
  • Indications Malignant melanoma
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-006
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 15 Sep 2024 According to a Merck & Co media release, ten-year OS data from this study showing sustained improved survival outcomes for patients receiving KEYTRUDA as a single agent compared to ipilimumab in patients with advanced melanoma, will be published in the Annals of Oncology.
    • 04 Sep 2024 According to a Merck & Co media release, ten-year OS data from this study will be presented at the European Society for Medical Oncology (ESMO) Congress 2024 in Barcelona, Spain, from Sept. 13-17.
    • 22 Jun 2023 Results assessing efficacy of 7-year follow-up published in the Journal of Clinical Oncology.

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