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A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Combination of Trastuzumab and Pertuzumab With or Without Concurrent Taxane Chemotherapy Given for Twelve Weeks in Patients With Operable HER2+/HR- Breast Cancer Within the ADAPT Protocol [SUBSTUDY OF 700216591]

Trial Profile

A Prospective, Randomized Multicenter, Open-label Comparison of Preoperative Combination of Trastuzumab and Pertuzumab With or Without Concurrent Taxane Chemotherapy Given for Twelve Weeks in Patients With Operable HER2+/HR- Breast Cancer Within the ADAPT Protocol [SUBSTUDY OF 700216591]

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 24 Jul 2019

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At a glance

  • Drugs Pertuzumab (Primary) ; Trastuzumab (Primary) ; Paclitaxel
  • Indications Breast cancer
  • Focus Biomarker; Therapeutic Use
  • Acronyms ADAPT-HER2+HR-
  • Most Recent Events

    • 31 Aug 2018 Biomarkers information updated
    • 07 Jun 2016 The DSMB recommended premature study closure due to a clear superiority of the Pac-containing arm and a <1% probability for demonstrating non-inferiority with the preplanned sample size, as per an abstract presented at the 52nd Annual Meeting of the American Society of Clinical Oncology
    • 07 Jun 2016 Status changed from recruiting to discontinued, as per an abstract presented at the 52nd Annual Meeting of the American Society of Clinical Oncology
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