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Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer - Triple Negative Breast Cancer [SUBSTUDY OF 700216591]

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Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer - Triple Negative Breast Cancer [SUBSTUDY OF 700216591]

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 09 Feb 2024

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At a glance

  • Drugs Paclitaxel (Primary) ; Carboplatin; Gemcitabine
  • Indications Carcinoma; Early breast cancer; Triple negative breast cancer
  • Focus Biomarker; Therapeutic Use
  • Acronyms ADAPT; WSG-ADAPT TN
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 23 Mar 2023 Planned End Date changed from 1 May 2020 to 1 Oct 2024.
    • 02 Sep 2022 Results assessing the impact of stromal tumor-infiltrating lymphocytes dynamics during neoadjuvant chemotherapy on pCR and survival in triple-negative early breast cancer, published in the Breast Cancer Research.
    • 08 Jun 2021 Results of a NGS-based mutational analysis assessing distribution of tumor mutations in BC-associated genes and impact of BRCA mutation status on pCR and outcome ; performed on DNA derived from pretreatment FFPE samples presented at the 57th Annual Meeting of the American Society of Clinical Oncology

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