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A randomised phase II study comparing LEnalidomide plus rituximab, GEmcitabine and methylprednisolone (LR-GEM) to rituximab, gemcitabine, methylprednisolone and cisplatiN (R-GEM-P) in second-line treatment of Diffuse Large B-cell lymphoma (DLBCL)

Trial Profile

A randomised phase II study comparing LEnalidomide plus rituximab, GEmcitabine and methylprednisolone (LR-GEM) to rituximab, gemcitabine, methylprednisolone and cisplatiN (R-GEM-P) in second-line treatment of Diffuse Large B-cell lymphoma (DLBCL)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 20 Sep 2019

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At a glance

  • Drugs Lenalidomide (Primary) ; Cisplatin; Gemcitabine; Methylprednisolone; Methylprednisolone; Rituximab
  • Indications Diffuse large B cell lymphoma
  • Focus Therapeutic Use
  • Acronyms LEGEND
  • Most Recent Events

    • 16 Sep 2019 Planned End Date changed from 28 Feb 2016 to 1 Aug 2023.
    • 31 Aug 2018 Biomarkers information updated
    • 12 Dec 2017 Status changed from recruiting to discontinued due to moderate response rates in both arms, as per results presented at the 59th Annual Meeting and Exposition of the American Society of Hematology.
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