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A Phase 2, Randomized, Multicenter Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Combined With Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Previously Untreated Pancreatic Cancer

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A Phase 2, Randomized, Multicenter Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Combined With Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Previously Untreated Pancreatic Cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Hyaluronidase (Primary) ; Dexamethasone; Enoxaparin sodium; Gemcitabine; Paclitaxel
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Halozyme Therapeutics

    • Most Recent Events

    • 04 Jun 2019 Results assessing Exposure-response analysis of efficacy of pegvorhyaluronidase alfa in combination with nab-paclitaxel + gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma published in conjunction with 55th Annual Meeting of the American Society of Clinical Oncology (2019).
    • 19 Jan 2019 Results assessing plasma hyaluronan (n=260) presented at the 2019 Gastrointestinal Cancers Symposium
    • 17 Oct 2018 Status changed from active, no longer recruiting to completed.

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