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A Randomised, Open-label, Phase III Study to Evaluate the Efficacy and Safety of Oral Afatinib (BIBW 2992) Versus Intravenous Methotrexate in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma Who Have Progressed After Platinum-based Therapy

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Trial Profile

A Randomised, Open-label, Phase III Study to Evaluate the Efficacy and Safety of Oral Afatinib (BIBW 2992) Versus Intravenous Methotrexate in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma Who Have Progressed After Platinum-based Therapy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Feb 2025

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At a glance

  • Drugs Afatinib (Primary) ; Methotrexate
  • Indications Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Oropharyngeal cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms LUX-Head and Neck-3
  • Sponsors Boehringer Ingelheim

Most Recent Events

  • 04 Feb 2025 Status changed from active, no longer recruiting to completed.
  • 31 Oct 2024 Planned End Date changed from 30 Apr 2025 to 31 Jan 2025.
  • 23 Sep 2024 Planned End Date changed from 31 Oct 2024 to 30 Apr 2025.

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