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Phase I/II Study of Immunotherapy for Advanced CD19+ Chronic Lymphocytic Leukemia, Acute Lymphoblastic Leukemia/Lymphoma and Non-Hodgkin Lymphoma With Defined Subsets of Autologous T Cells Engineered to Express a CD19-Specific Chimeric Antigen Receptor

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Trial Profile

Phase I/II Study of Immunotherapy for Advanced CD19+ Chronic Lymphocytic Leukemia, Acute Lymphoblastic Leukemia/Lymphoma and Non-Hodgkin Lymphoma With Defined Subsets of Autologous T Cells Engineered to Express a CD19-Specific Chimeric Antigen Receptor

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 25 Jul 2023

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At a glance

  • Drugs JCAR 014 (Primary) ; Cyclophosphamide; Fludarabine
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma; Richter's syndrome
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 15 Jun 2023 Results (n=49) in patients with R/R CLL and/or Richters transformation, presented at the 28th Congress of the European Haematology Association
    • 06 Jun 2023 Results (N=49)of five-year follow-up update of defined-composition CD19 CAR T-cell therapy for relapsed/refractory CLL, presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 19 Apr 2022 Results published in the Blood

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