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A 2-part Phase III Randomized, Open Label, Multicenter Study of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma

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A 2-part Phase III Randomized, Open Label, Multicenter Study of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 26 Dec 2024

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Vemurafenib
  • Indications Malignant melanoma
  • Focus Registrational; Therapeutic Use
  • Acronyms COLUMBUS
  • Sponsors Array BioPharma; Novartis; Pfizer

    • Most Recent Events

    • 11 Oct 2024 Status changed from active, no longer recruiting to completed.
    • 29 Aug 2024 This trial has been completed in Portugal, according to European Clinical Trials Database record.
    • 27 Aug 2024 Planned End Date changed from 15 Jul 2024 to 31 Aug 2024.

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