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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction (PARAGON-HF)

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Trial Profile

A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction (PARAGON-HF)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 18 Oct 2024

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At a glance

  • Drugs Sacubitril/valsartan (Primary) ; Valsartan
  • Indications Chronic heart failure
  • Focus Registrational; Therapeutic Use
  • Acronyms PARAGON-HF
  • Sponsors Novartis; Novartis Pharma KK; Novartis Pharmaceuticals

Most Recent Events

  • 02 Sep 2024 Results (n=4795) assessing changes in hemoglobin, risks of incident anemia and new oral iron initiation during follow-up and treatment effects on the primary composite endpoint of total HF hospitalizations (HFH) and cardiovascular (CV) death according to anemia status were presented at the ESC Congress 2024 - Annual Congress of the European Society of Cardiology.
  • 01 Sep 2024 Results published in the Circulation: Heart Failure
  • 08 Apr 2024 Results assessing abdominal obesity and outcomes in heart failure with preserved ejection fraction presented at the 73rd Annual Scientific Session of the American College of Cardiology.

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