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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction (PARAGON-HF)

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A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) With Preserved Ejection Fraction (PARAGON-HF)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 03 Sep 2024

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At a glance

  • Drugs Sacubitril/valsartan (Primary) ; Valsartan
  • Indications Chronic heart failure
  • Focus Registrational; Therapeutic Use
  • Acronyms PARAGON-HF
  • Sponsors Novartis; Novartis Pharma KK; Novartis Pharmaceuticals

    • Most Recent Events

    • 08 Apr 2024 Results assessing abdominal obesity and outcomes in heart failure with preserved ejection fraction presented at the 73rd Annual Scientific Session of the American College of Cardiology.
    • 08 Apr 2024 Results evaluating associations between hypotension and outcomes from this trial presented at the 73rd Annual Scientific Session of the American College of Cardiology.
    • 20 Dec 2023 Results assessing whether higher BUN/Cr is associated with worse outcomes in patients with chronic HF by deriving data from PARADIGM-HF, ATMOSPHERE & DAPA-HF and PARAGON-HF & I-PRESERVE, published in the European Journal of Heart Failure

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