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A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)

Trial Profile

A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with primary osteoarthritis of the knee (FORWARD)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 19 Nov 2019

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At a glance

  • Drugs Sprifermin (Primary)
  • Indications Osteoarthritis
  • Focus Therapeutic Use
  • Acronyms FORWARD
  • Sponsors EMD Serono; Merck KGaA
  • Most Recent Events

    • 08 Oct 2019 Results evaluating effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients with osteoarthritis, published in the Journal of the American Medical Association (JAMA).
    • 08 Oct 2019 Status changed from active, no longer recruiting to completed, according to an EMD Serono media release.
    • 08 Oct 2019 According to an EMD Serono media release, data of a post-hoc, exploratory analysis from this trial will be featured as an oral presentation at the upcoming 2019 American College of Rheumatology (ACR) Annual Meeting.
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