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An Open-label, Non-randomised, Multicentre, Comparative, Phase I Study to Determine the Pharmacokinetics, Safety and Tolerability of Olaparib Following a Single Oral 300 mg Dose to Patients With Advanced Solid Tumours and Normal Hepatic Function or Mild or Moderate Hepatic Impairment

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Trial Profile

An Open-label, Non-randomised, Multicentre, Comparative, Phase I Study to Determine the Pharmacokinetics, Safety and Tolerability of Olaparib Following a Single Oral 300 mg Dose to Patients With Advanced Solid Tumours and Normal Hepatic Function or Mild or Moderate Hepatic Impairment

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 07 Nov 2021

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At a glance

  • Drugs Olaparib (Primary)
  • Indications Solid tumours
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca
  • Most Recent Events

    • 29 Mar 2020 Results published in the British Journal of Clinical Pharmacology
    • 24 Mar 2017 Status changed from active, no longer recruiting to completed.
    • 18 Mar 2017 Results (n=67) assessing pharmacokinetics and safety of olaparib using patient data from NCT01894256 and NCT01894243 trials, presented at the 118th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
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