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A Phase I/IIa Sporozoite Challenge Study to Assess the Safety and Protective Efficacy of the Combination Malaria Vaccine Candidate Regimen of RTS,S/AS01B + ChAd63 and MVA Encoding ME-TRAP and Also RTS,S/AS01B Alone.

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Trial Profile

A Phase I/IIa Sporozoite Challenge Study to Assess the Safety and Protective Efficacy of the Combination Malaria Vaccine Candidate Regimen of RTS,S/AS01B + ChAd63 and MVA Encoding ME-TRAP and Also RTS,S/AS01B Alone.

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 08 Sep 2023

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At a glance

  • Drugs GSK 257049 (Primary) ; ME-TRAP malaria DNA vaccine Okairos (Primary)
  • Indications Malaria
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 10 Feb 2018 Results of pooled analysis of this and other five phase II studies assessing relationship between HLA allele groups and RTS,S-mediated protection in controlled human malaria infections, published in the Vaccine.
    • 15 Jun 2016 Results from phase II part of the study published in the Journal of Infectious Diseases
    • 30 Sep 2014 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.

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