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A Multicenter, Open-label, Phase 1b Study of MLN0128 (an Oral mTORC1/2 Inhibitor) in Combination With MLN1117 (an Oral PI3K alpha Inhibitor) in Adult Patients With Advanced Nonhematologic Malignancies

Trial Profile

A Multicenter, Open-label, Phase 1b Study of MLN0128 (an Oral mTORC1/2 Inhibitor) in Combination With MLN1117 (an Oral PI3K alpha Inhibitor) in Adult Patients With Advanced Nonhematologic Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 04 Nov 2019

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At a glance

  • Drugs Sapanisertib (Primary) ; Serabelisib (Primary)
  • Indications Haematological malignancies; Solid tumours
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Takeda Oncology
  • Most Recent Events

    • 24 Aug 2018 Status changed from active, no longer recruiting to completed.
    • 19 Jan 2018 Planned End Date changed from 1 May 2017 to 30 Jun 2018.
    • 02 Dec 2016 Results assessing safety, pharmacokinetics, pharmacodynamics and preliminary activity of TAK-228 + TAK-117 (n=77) presented at the 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.
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