A Phase II, Open-label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of MPDL3280A (Anti−PD-L1 Antibody) Compared With Docetaxel in Patients With Non−Small Cell Lung Cancer After Platinum Failure

Trial Profile

A Phase II, Open-label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of MPDL3280A (Anti−PD-L1 Antibody) Compared With Docetaxel in Patients With Non−Small Cell Lung Cancer After Platinum Failure

Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Aug 2018

At a glance

  • Drugs Atezolizumab (Primary) ; Docetaxel
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms POPLAR
  • Sponsors Roche
  • Most Recent Events

    • 26 Jun 2018 Planned End Date changed from 1 May 2018 to 31 Jul 2018.
    • 05 Jun 2018 Results of a large retrospective analysis associating tTMB with neoantigen load and efficacy using pooled data from multiple studies (FIR, BIRCH, POPLAR, OAK; NSCLC n= 342), (IMvigor210, 211; metastatic urothelial carcinoma n=400) and (PCD4989g; other advanced solid tumors n=245), presented at the 54th Annual Meeting of the American Society of Clinical Oncology.
    • 23 Apr 2018 Results published in the Clinical cancer research: an official journal of the American Association for Cancer Research
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