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S1304, A Phase II Randomized Study Comparing Two Doses of Carfilzomib (NSC-756640) With Dexamethasone for Multiple Myeloma Patients With Relapsed or Refractory Disease

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Trial Profile

S1304, A Phase II Randomized Study Comparing Two Doses of Carfilzomib (NSC-756640) With Dexamethasone for Multiple Myeloma Patients With Relapsed or Refractory Disease

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 24 Apr 2023

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At a glance

  • Drugs Carfilzomib (Primary) ; Dexamethasone
  • Indications Multiple myeloma
  • Focus Therapeutic Use

    • Most Recent Events

    • 13 Dec 2022 Results of secondary analysis (n=123) assessing the incidence, timing, nature, and potential risk-factors of carfilzomib-induced renal toxicity using data from S1304 which compared two doses of carfilzomib (56 mg/m2 (K56) vs 27 mg/m2 (K27) twice-weekly), both with dexamethasone, in relapsed/refractory myeloma, presented at the 64th American Society of Hematology Annual Meeting and Exposition.
    • 16 Apr 2020 Interim Results evaluating a benefit of fixed-duration, twice-weekly 56 mg/m(2) dosing of carfilzomib over the 27 mg/m(2) dose for the treatment of relapsed and/or refractory MM, published in the Clinical Cancer Research
    • 03 Apr 2020 Status changed from active, no longer recruiting to completed.

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